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"Newborn Screening in Japan--2021" is a topical collection of the International Journal of Neonatal Screening. Japan's newborn mass screening (NBS) was started in 1977 at the national level as a national project. Subsequently, screening was conducted for six diseases. From 2014 a tandem mass analyzer (tandem mass) was introduced nationwide, and in addition to the conventional amino acid metabolism disorders urea cycle disorders, organic acid metabolism disorders and fatty acid metabolism disorders have joined the target diseases. Screening is currently conducted for 20 diseases. The acceptance rate of mass screening in Japan is 100%, and top-level screening measures available in the world, such as a quality control system and an inspection system, are carried out. This book is an overview of the history, current status and future of NBS in Japan. I hope that readers are interested in this book.
Children --- Medical screening --- Diseases --- Diagnosis.
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Die aktuelle Ausgabe des Versorgungs-Reports greift die versorgungswissenschaftliche Diskussion um Chancen und Risiken der Früherkennung auf. Namhafte Expertinnen und Experten beleuchten aktuelle Entwicklungen und Herausforderungen bei der Früherkennung von Krankheiten. Im Fokus stehen: - gesundheitswissenschaftliche Konzepte und Methoden der Früherkennung - wissenschaftliche Erkenntnisse über Nutzen und Risiken ausgewählter Screenings - Entwicklung und Anforderungen an ausgewogene, evidenzbasierte Informationsangebote - empirische Analysen zur Akzeptanz und Inanspruchnahme von Früherkennungsuntersuchungen in der gesetzlichen Krankenversicherung Der Teil "Daten und Analysen" informiert auf der Grundlage von AOK-Abrechnungsdaten über die Häufigkeit von Erkrankungen und Behandlungen in Deutschland: - Behandlungsprävalenzen und Hospitalisierungsraten für die häufigsten Erkrankungen, differenziert nach Alter und Geschlecht - Krankenhausbehandlungen, Arznei- und Heilmittelverordnungen sowie ärztliche Inanspruchnahme
Medical screening --- Medicine --- screening --- evidence --- risk --- benefit --- shared desicion making --- decision-making
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Recoge: 1. Introduction -- 2. Organisation -- Guiding principles for organising a colorectal cancer screening programme -- 3. Evaluation and interpretation of screening outcomes -- 4. Faecal occult blood testing -- 5. Quality assurance in endoscopy in colorectal cancer screening and diagnosis -- 6. Professional requirements and training -- 7. Quality assurance in pathology in colorectal cancer screening and diagnosis -- 8. Management of lesions detected in colorectal cancer screening -- 9. Colonoscopic surveillance following adenoma removal --10. Communication -- Appendices.
Rectum --- Colon (Anatomy) --- Medical screening --- Cancer colorectal --- Dépistage (Médecine) --- Cancer --- Quality control --- Qualité --- Contrôle --- E-books --- Dépistage (Médecine) --- Qualité --- Contrôle --- Mass medical screening --- Mass screening, Medical --- Medical examinations --- Screening, Medical --- Diagnostic services --- Health risk assessment --- Colorectum --- Intestine, Large --- Cancer&delete& --- Diagnosis
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In the genomic era of 1990s-2000s, pharmaceutical research moved to target-based drug discovery which enabled development of a number of small molecule drugs against a wide range of diseases. In many cases however, drugs that arose from genomics failed, questioning the validity of the targets and the suitability of target-based drug discovery as an optimal strategy for all disease states. For monogenic diseases, target-based approaches may be well-suited to the identification of novel therapies. Most diseases, however, are caused by a combination of several genetic and environmental factors and are likely to require simultaneous modulation of multiple molecular targets/pathways for successful treatment. For such diseases, reductionist approaches focusing on individual targets rather than biological networks are unlikely to succeed and new drug development strategies are required. In search of more successful approaches, the pharmaceutical industry is moving towards phenotypic screening beyond individual genes/targets. However, this requires rethinking of diseases and drug discovery approaches from a network and systems biology perspective. Since returning to the pre-genomics era of screening drug candidates in laborious animal models is not a feasible solution, the industry needs to evolve a new paradigm of phenotypic drug discovery within the context of systems biology. Such a paradigm must combine physiologically and disease relevant biological substrates with sufficient throughput, operational simplicity and statistical vigour. Biomarker strategies for translational medicine, as well as preclinical safety and selectivity assessments, would also need to be revised to adapt to the target agnostic style. This focused issue aims to discuss strategies, key concepts and technologies related to systems-based approaches in drug development. Design and implementation of innovative biological assays, featuring multiple target strategies, and rational drug design in the absence of target knowledge during the early drug discovery are illustrated with examples.
Medical screening --- Drug development. --- Pharmacology. --- Phenotype. --- label-free technologies --- gene networks --- pathways --- Phenotypic screenning --- Drug Discovery --- Systems Biology --- target-based assays --- panomic data --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Development of drugs --- New drug development --- Pharmacology --- Mass medical screening --- Mass screening, Medical --- Medical examinations --- Screening, Medical --- Diagnostic services --- Health risk assessment --- Physiological effect --- Development
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This book ""New Insights into Toxicity and Drug Testing"" covers all emerging technologies (profiling technologies, 3D cultures, next generation sequencing etc.), available methods and models to evaluate candidate drugs and medicinal plants with reference to toxicity, drug testing and development. This book is an original contribution of experts from different parts of the globe and the in-depth information will be a significant resource for scientists and physicians who are directly dealing with drugs / medicines and human life.
Drug testing. --- Drugs --- Toxicology. --- Drug toxicity --- Drug abuse --- Drug abuse screening --- Screening for drug abuse --- Testing for drug abuse --- Medical screening --- Side effects --- Testing --- Toxicology --- Toxicology and Pharmaceutical Science --- Pharmacology --- Medical Toxicology --- Health Sciences
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